The fourth largest river in Africa, the Zambezi provides a permanent lifeline for the reserve, attracting large herds of elephant, buffalo and other large mammals in the dry winter months. Just 38 km (24 miles) above Victoria Falls, the Zambezi at Matetsi is broad and dotted with small islands. Nile crocodile and Cape clawless otter frolic in the river’s waters, taking full advantage of the more than 80 species of fish found in the Zambezi, while immense hippo venture out onto the river’s banks to graze at night. Birds are abundant on the floodplains, as are waterbuck and herds of elephant and buffalo.

With a number of small, seasonal rivers running into the Zambezi, the many river valleys with their easy access to water are among the most rewarding areas for game viewing. Nutritious grasses fed by underground water and abundant acacias attract both browsers and grazers. Kudu, impala, warthog, buffalo and elephant are frequently encountered, as well as lion, spotted hyena, leopard, cheetah and African wild dog. Numerous birds, ranging from brightly coloured hornbills and barbets to more modest doves and francolins, can be seen. Large trees along the river banks provide nesting sites for all types of eagles and hawks, as well as vultures and other raptors.

Large parts of Matetsi are covered in Kalahari woodland, a flat or gently undulating landscape dominated by deciduous trees. During the dry winter months, these woodlands can become sparse and barren, with animals staying away in favour of the perennial river banks. By November, during the rainy season, the woodlands are transformed into a verdant, leafy forest. Sparse grass cover supports zebra, the rare roan and sable antelope, as well as the nocturnal aardvark and aardwolf. The southern parts of Matetsi are covered with a dramatically different type of vegetation, the dense mopane woodland, which attracts herds of elephant, buffalo, kudu, roan and eland.